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당뇨쥐에서 임플란트 즉시 식립 후 조직계측학적 연구를 통한 임플란트 골유착 비교
Histomorphometric Study of New Bone Formation Around Immediately Placed Titanium Implant on the Extraction Socket of Diabetic and Insulin Treated Rat

대한통합치과학회지 2016년 5권 2호 p.61 ~ 66

김성민, 박수현, 허현아, 표성운,

소속 상세정보

김성민 ( Kim Sung-MIn ) - 가톨릭대학교 임상치과학대학원 구강악안면외과
박수현 ( Park Su-Hyun ) - 가톨릭대학교 의과대학 치과학교실 구강악안면외과
허현아 ( Heo Hyun-A ) - 가톨릭대학교 의과대학 치과학교실 구강악안면외과
표성운 ( Pyo Sung-Woon ) - 가톨릭대학교 의과대학 치과학교실 구강악안면외과

KMID : 1146620160050020061

Abstract

Introduction: Dental implants are routinely used with high success rates in generally healthy individuals. By contrast, their use in patients with diabetes mellitus remains controversial as altered bone healing around implants has been reported. The present study aimed to investigate the bone healing response around immediately placed titanium implants in the rats with controlled and uncontrolled diabetes.

Materials and Methods: Twenty rats were divided into the control, insulin-treated and diabetic groups. The rats received streptozotocin (60 mg/kg) to induce diabetes; animals in the insulin-treated group also received three units of subcutaneous slow-release insulin. A titanium implant (1.2×3 mm) was placed in the extraction socket of the maxillary
first molar and was harvested at 2 and 4 weeks. After routine process of histologic process, section were measured for
Bone-implant contact, bone density using Image analysis program.

Results: After 2 weeks post-implantation, BCR (Bone contract ratio) of the control, the diabetic group and insulintreated group was 42.62%, 24.55% and 27.75%, respectively. The BCR of the control was lower than the diabetic group and insulin-treated group. After 4 weeks post-implantation, BCR (Bone contract ratio) of the control, the diabetic group and insulin-treated group was 45.32%, 39.14% and 43.84%, respectively. Also, the results of bone density was showed a similar pattern of the results of BCR.

Conclusion: The immediate placement of titanium implants in the maxilla of controlled diabetic rat led to a wanted bone healing response. In conclusion, the results of this study suggest that immediate implant insertion in patients with controlled diabetes might be indicated.